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10.1007/s10654-024-01138-038992218 114 Yang Y, Zhang X, Jin Z, et al

IV administration overcomes this hurdle, enabling the body to achieve significantly higher, pharmacologic concentrations that cannot be reached orally

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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012