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However, the study has some limitations

Funding This work was supported by the National Natural Science Foundation of China (31970699), the Guangdong Basic and Applied Basic Research Foundation (2021A1515010766 and 2019A1515011030), the Guang-dong Provincial Key Laboratory of Construction Foundation(2019B030301005), the Key-Area Research and Development Program of Guangdong Province (2020B1111110003), and the National Major Special Projects for the Creation and Manufacture of New Drugs(2019ZX09301104)