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Description

The MR-Base platform supports systematic causal inference across the human phenome

Global metabolomics G-Met analyses of the aqueous humor samples from control subjects (total, n = 37: cataract, n = 12

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Disruption of this integrated network (e.g., via ferroptosis inhibitors targeting ACSL4/GPX4, anti-inflammatory agents blocking HMGB1/IL-33, or HIF modulators balancing hypoxia adaptation) can break the pathogenic cycle, highlighting the therapeutic potential of targeting the networks central nodes rather than individual pathways