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The researchers wrote that while it wasn't clear whether the same relationship would apply to regions of the genome that code for proteins, "our data suggest that paternal exposure to second-hand smoke may have reproductive consequences that go beyond the passive smoker." Marchetti said that the findings provided "compelling evidence in support of the argument that passive smoking should be regarded as a germ cell mutagen in humans"

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Sugar is also added to make the resulting cigarette less harsh, but this addition leads to the formation of acetaldehyde, which is a type of carcinogen that enhances the addictiveness of nicotine