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Furthermore, when apoptosis and necroptosis fail to occur, caspase-8 can be involved in the activation of caspase-1 and inflammasome to trigger pyroptosis, a strongly proinflammatory cell death modality associated with the release of IL-1 and IL-18 [145, 146]

In comparison with the S-1 plus cisplatin treatment, the median overall survival time was 13 months and the median progression-free survival time was 6 months [163]

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Oral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial