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While regulating the long non-coding RNA/miRNA pathway offers high specificity, the systemic delivery of RNA-modulating drugs poses challenges, such as the risk of off-target effects, obstacles in clinical scalability, and challenges in targeting efficacy (117)

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The GPX5 gene is located on chromosome 6p22.1 and is composed of 7 exons that generate two alternatively spliced mRNAs encoding two protein isoforms