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The resultant increases in heart rate, blood pressure, contractility and peripheral vascular resistance imbalances the myocardial oxygen supplydemand ratio which makes the heart vulnerable for ischaemic damage.[10] Respiratory system The irritants and ciliotoxins present in tobacco smoke increases mucous production and weakens the mucus clearance mechanism in the tracheobronchial tree.[11] This leads to clogging of the lungs with hyperviscous thick mucus secretion, bacteria and dead cells making lungs vulnerable to various infections.[12] An increase in proteolytic and elastolytic enzymes leads to loss of elasticity and emphysema

A study published in the British Medical Journal found that smoking cessation is associated with reduced depression, anxiety, and stress, and improved positive mood and quality of life compared with continuing to smoke. The benefits were particularly marked for those subjects currently being treated with antidepressants

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