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Guirado E, Schlesinger LS

However, they also release neurotrophic factors in support of neurons 62 and they contribute to neuroprotection against glutamate excitotoxicity 63 and oxidative stress 64,65

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Factors Indicating Against Dose Escalation Maintain current dose when experiencing significant side effects at present level, achieving satisfactory subjective improvements (better sleep, energy, recovery), IGF-1 increased adequately (50+ ng/mL) for optimization goals, or financial constraints make higher dosing unsustainable