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[SOURCED] This bidirectional NO modulation distinguishes BPC-157 from simple NO donors or inhibitors and may explain its broad-spectrum cytoprotective effects across tissue types with divergent NO requirements

In explaining its decision, the agency flagged concerns about complexities with regard to peptide-related impurities and active pharmaceutical ingredient (API) characterization, the potential for aggregation and a lack of human safety data

Figure 1 3.1 Clostridium in IBD IBD is an outcome of a combination of exogenous and endogenous pathogenic factors acting on the intestinal immune system (57, 58) and is broadly categorized as ulcerative colitis (UC) and Crohns disease (CD) (59)

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