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While elevated MMA blood concentration is considered the specific indicator of deficiency (19), other clinical assays are often used as biomarkers of vitamin B 12 status sometimes in combination

3 Extracellular matrix stiffness The extracellular matrix (ECM) is a key component of the tumor microenvironment, providing structural support and acting as a reservoir of cues, including biophysical signals such as matrix stiffness and viscoelasticity