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There is a high heterogeneity of ECs surface and cytoplasmic markers [9]

Upon release, Nrf2 translocates to the nucleus where it can bind to the antioxidant response element (ARE) located in the promoter region of genes coding for antioxidant enzymes and scavengers

These targeted signaling molecules are either part of a signaling cascade, or transcription factor, or an enzyme that further generates signaling mediators (e -TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Based on current evidence, DKD patients are recommended to prioritize plant protein and fish protein while limiting red meat and processed meat consumption