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However, decreased responsiveness to VIM DBS by select body parts (possibly due to the somatotopic organization of the VIM nucleus) increased tolerance to VIM stimulation due to compensation or disease progression [176, 177], and the development of adverse side effects, such as dysarthia and dysphagia [174], in patients, has driven efforts to optimize DBS targeting

GHK-Cu Titration Protocols: A Biomarker-Informed Framework Titration strategies for GHK-Cu are individualized, typically starting at lower doses and increasing over 412 weeks based on clinical response, injection site tolerance, and biomarker trends

PLoS ONE 7 , e31812 (2012)

At the very center of this biochemical storm is a vital molecule known as glutathione