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When exposed to zinc in vitro , DCs derived from bone marrow exhibited a tolerogenic profile, characterized by reduced surface MHC-II expression and increased levels of tolerogenic markers such as Programmed Death-Ligand (PD-L) 1, PD-L2 and the tryptophan degrading enzyme, Indoleamine 2,3-dioxygenase (IDO)

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Further studies are needed to assess the frequency of such mutations among patients and explore ways to inhibit its activity and restore sensitivity to hormonal therapy [51]

Together, these results highlight the crucial role of carnitine biosynthesis via SLC25A45 in fuel switching from carbohydrates to fatty acids in response to cold acclimation, as well as GLP-1RA-induced body weight loss