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Globally available over-the-counter 9 Included in: WHO policy recommendation and Model List of Essential Medicine since 2009 30-32 European Network for Smoking and Tobacco Prevention (ENSP) Tobacco Dependence Treatment Guidelines 33 NRT Combination Therapy is recommended by NICE as a first-line treatment option8 NRT single therapy is recommended by NICE as a second-line treatment option 8 Cytisine: Suitable for 18+18 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2024 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Under consultation to add as first line treatment option 8 Varenicline: Suitable for 18+ 19 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2021 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Varenicline is recommended by NICE as a first-line treatment option 8 Bupropion: Suitable for 18+20 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2021 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Bupropion is recommended by NICE as a second-line treatment option 8 To keep in mind: NRT Combination Therapy is one of the most effective ways to help your patient quit for good 8 Speed of action and cravings relief Observational field studies indicate that cue-induced cravings are substantially responsible for relapse to smoking 35

Genes were identified as differentially expressed if they met both an FDR-adjusted p -value 1

This study conducted a secondary analysis of data from the KYRBS, an anonymous, self-administered online survey implemented annually since 2005 by the Korea Disease Control and Prevention Agency (KDCA)