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Couto, N., Wood, J., & Barber, J

By detecting the effect of NW on H 2 S production in different tissue homogenates, it was found that NW increased H 2 S production in the heart, aorta, and kidney

Completed Phase II and III clinical trials have indicated that the agent has a nonoverlapping toxicity profile and synergistic effects with carboplatin, paclitaxel, and anthracycline, has no cross-drug resistance and is well tolerated, with patients mostly reporting fatigue and nausea

Among the immediate-early response genes, expression of c-Jun and c-Fos is induced to form the transcription factor AP-1 that regulates transcription of genes implicated in cell proliferation or differentiation