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People can usually manage their bee sting symptoms using over-the-counter creams and oral medications, including: hydrocortisone creams, which can help reduce redness, itching, swelling, and pain oral antihistamines, which can help reduce itching and redness pain relievers and anti-inflammatories, which can reduce pain and swelling Treatment for severe allergic reactions If a person experiences a severe allergic reaction, they may require an immediate epinephrine injection to counteract life-threatening symptoms called anaphylaxis