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doi: 10.1038/s41590-021-00962-w 241 SartoriusR.TrovatoM.MancoR.DApiceL.De BerardinisP

Another study demonstrated that CHE induced cell apoptosis and increased ROS generation by inducing the permeability and rupture of the mitochondrial membrane, thereby inducing apoptosis of DL cells by releasing cyt-c and activating Apaf-1 and the cleavage of caspase-9,3 (Kumar and Acharya, 2014)