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in vitro in vivo,

The peptide's natural occurrence in the body, well-established safety profile from decades of topical use and clinical research, and remarkable breadth of beneficial biological effects make it a compelling example of a naturally derived regenerative peptide with both proven cosmetic applications and ongoing exploration of broader therapeutic potential

Yuan and Hochschild, 2017

Likely, the distinctive achievement of complete reattachment in the rats could be due to the greater forces acting on the rectus femoris muscle, which extends over two joints (biarticular) and has two functions (auxiliary hip flexor, knee extensor), as well as the fact that this muscle is completely separated from its origin