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[83] Thus, modulation of NAD + metabolism has been investigated in the context of cancer, radiation response, and aging

On the other hand, the use of animal models to study invasive meningococcal disease, in addition to presenting the obvious difficulties in investigating aspects of the extracellular/intracellular phase of meningococcal infection, is hampered by the fact that meningococcus has a very narrow host specificity, essentially restricted to humans

[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs

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