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10.3389/fphys.2019.01323 109 NakataniS.IshimuraE.MuraseT.NakamuraT.NakataniA.ToiN.et al (2021)
Differences between the outcome of recurrent acute pancreatitis and acute pancreatitis
A way to explain cell death associated with reduced levels of GSH is ferroptosis, a unique iron-dependent form of non-apoptotic cell death, characterized by lipid peroxidation with ROS accumulation due to GSH peroxidase inactivation and high levels of GSH consumption
This evidence supports a multi target therapeutic paradigm that is consistent with the multifactorial nature of ASD and suggests that combined interventions, for example, omega3 with vitamin D or vitamin E, or cysteine rich proteins to boost glutathione, may exert additive or synergistic effects across redox, mitochondrial, and immune pathways (Castejon et al., 2021
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