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Loop diuretics: from the Na-K-2Cl transporter to clinical use

Not having sufficient levels of vitamin B12 can lead to health issues such as generalized weakness, numbness, leg stiffness, abnormal gait, memory loss, personality change, and a depressed mood

References Rosamond W, Flagel K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell CJ, Roger V, Rumsfeld J, Sorlie P, Steinburger J, Thom T, Wasserthiel-Smoller S, Hong Y, American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)