During this process, partial electron transfer via NADPH-CYP450 reductase to the CYP450-substrate complex results in "electron leakage", leading to the incomplete reduction of O to O 2 or HO [129]
Berardi S, Stieger B, Wachter S, ONeill B, Krahenbhl S (1998) Characterization of a sodium-dependent transport system for butyrobetaine into rat liver plasma membrane vesicles
10.1038/onc.2014.207
Interestingly, the two drugs both strongly affected eight inflammation-related signaling pathways: chemokine signaling, cytokine-cytokine receptor interaction, MAPK signaling, IL-17 signaling, NOD-like receptor signaling, TGF-beta signaling, TNF signaling, and pathways in cancer (Figure 8A, the intersection of the orange box and green box)