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The Potential of Retatrutide Retatrutide leads to 24.2% mean WL at the highest dose after 48 weeks in people with obesity, with no evidence of plateau and up to 26% of participants achieving 30% WL - approaching the efficacy Roux-en-y gastric bypass, one of the most effective BS procedures

The authors of both studies attributed the results to an improvement in the intestinal absorption of fluids and electrolytes and possibly increased skeletal muscle uptake causing greater neuromuscular performance, besides a possible gluconeogenic effect of alanine, sparing muscle glycogen, and retarding fatigue [144, 146]

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& Daglioglu, C