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OXY diminished macrophage sensitivity to LPS stimulation, resulting in reduced expression of inflammatory cytokines such as IL-1, IL-6, and TNF-, while simultaneously augmenting sensitivity to IL-4 stimulation, leading to enhanced expression of M2-type genes accompanied by suppression of NF-B signaling (Tang et al., 2019)

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Cell proliferation and apoptosis can also be controlled by LA via activating extracellular regulated protein kinase 1/2 (ERK 1/2) [42], protein kinase C (PKC) [43], and mitogen-activated protein kinase (MAPK) [44]