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Augmenting NAD(+) may combat kidney stress

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The method of embodiment12, wherein the INK inhibitor is SP600125

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ATF6-mediated transcriptional activation of PLA2G4A confers ferroptosis resistance, whereas pharmacological inhibition of ATF6 (e.g., Ceapin-A7) synergizes with enzalutamide to suppress CRPC growth (205)

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120 In myeloid cell-specific SIRT1 knockout mice, lipid toxicity or LPS stimulation induced more severe hepatic inflammation, elevated pro-inflammatory cytokine levels, and enhanced M1 macrophage polarization, highlighting the critical role of SIRT1 in preserving immune balance

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