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The nuclear glutathione pool is more resistant to depletion by BSO than the cytosolic as it was demonstrated in 3T3 fibroblasts and other human cell lines 87,88 , hence we cannot exclude the possibility that AITC -which presumably acts differently from BSO- is able to deplete efficiently the nuclear pool

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Additionally, no new nanomedicines have been approved by the Food and Drug Administration (FDA) or European Medicines Agency (EMA) for RA between 2023 and 2025, highlighting significant gaps in translating laboratory innovations into clinical practice (54)

It is imperative to seek prompt surgical surgery to avoid appendix rupture, which may lead to potentially fatal complications such as peritonitis