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AOD9604 represents part of a broader scientific effort to develop targeted therapies that can isolate beneficial effects of growth hormone while avoiding unwanted systemic effects, similar to the development of selective androgen receptor modulators (SARMs) or selective estrogen receptor modulators (SERMs) in other therapeutic areas

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TIP47 inhibits the hydrolysis of retinyl esters by GS2 and by HSL in human keratinocytes, suggesting that in adipocytes it may share a similar antilipolytic function with other PAT family proteins, such as perilipin or adipose differentiation-related protein/adipophilin (36)